When the quantity of the final product reaches a particular level during the fermentation process, repressor is a common issue. The release of the target molecule may also be suppressed and cell development may be inhibited by an excessive buildup of products in the culture. In order to eliminate product or byproducts inhibition and improve fermentation performance, it may be possible to combine fermentation and separate fermentative products or byproducts. Feedback inhibition affects the production of various antibiotics, amino acids, and fungal metabolites; the issue must be resolved to increase the product yield. However, byproduct inhibition can affect the production of some compounds by microorganisms like lactic acid bacteria and recombinant bacteria. Commercial operations of peptides and metabolites via microbial fermentation have considerably increased in recent years for industrial uses. For ensure that the method is profitable and that product prices are competitive, novel fermentation techniques must be created to replace the traditional ones. Numerous methods, including the use of fed-batch fermentation, adsorptive membranes, electro dialysis, and macro porous ion-exchange resins, have been suggested to address the issue of feedback repression and the buildup of unwanted byproducts in the culture. It may be possible to lessen feedback inhibition or the buildup of repressive byproducts by adding macro porous adsorbent resin to the culture and combining it with efficient fermentation. The product yield may then rise as a result of this. According to the facts above, it appears that using adsorbent resin to solve the issue of feedback inhibition brought on by the buildup of products and contaminant in the culture is extremely promising. For greater comprehension, research and development on this fermentation approach will be expanded to include different fermentation processes. The adsorption rate of a product or waste by a resin depends on the resin's properties and the matrix, so some general information about these is necessary. It is necessary to identify the critical elements in scaling up the process method. It is also necessary to have kinetic models that can be used to characterize the process and serve as guides for creating large-scale extractive fermentation that will improve the production of metabolites that are inhibited by products or byproducts. The properties of the resins and the matrix affected how well they could adsorb acetic acid. When comparison to strong base ionic resin, basic and acidic anion-exchange resin had a higher acetic acid absorption capacity and affinity When compared to growth without the input of resins, this method increased the production of recombinant interferon-b by around 1.8 times in a stirred tank bioreactor. The advent of bioreactor systems with in situ addition of alkali metal resin for removal efficiency of acetic acid may be employed for effective growing of E. coli recombinant strains for manufacturing of biotechnology products because the anion-exchange resins are reusable.