Global Journal of Interdisciplinary Social Sciences (GJISS) is a peer-reviewed International research journal published online. This journal offers a platform for scholars, academicians, professionals and students, to contribute interdisciplinary research from across the fields within the social sciences including, but not limited to : Anthropology, Arts & culture, Communication studies, Criminology, Cross-cultural studies in Demography, Economics, Education, English, Ethics, Geography, History, International relations, Law, Library science, Linguistics, Literature, Media studies, Political science, Psychology, Public administration, Sociology & Philosophy. The journal offers a global platform for the academia to elevate their scholarly image internationally as it reaches a wide spectrum of readers globally.

Human ageing is a protracted and intricate process. In order to comprehend the processes underlying the biological decrease of functions that occurs with age, model organisms must be used. Irreversible growth arrest is one of the characteristics of cellular senescence, among others. Senescent cells are thought to participate in processes including embryogenesis and wound healing in addition to inhibiting the growth of tumours in vivo. Additionally, the progression of ageing and the emergence of age-related disorders are linked to the persistence of senescent cells in specific organs. Senescence is a process that can be generated in vitro and is thought to be a beneficial tool for ageing research. Here, we go through the key mechanisms underlying cellular senescence as well as the distinguishing features of the many in vitro senescence types. We also go through various ways to activate senescent cells in culture as well as ways to spot them.

It was investigated whether murine oocytes aged in vitro for 2, 4, 6, and 8 hours following oocyte removal were competent to grow to the two-cell and blastocyst stage. The degree of H3K9me3 was examined in both the two-cell embryos produced by IVF and the aged postovulatory oocytes.

The guidelines in the German Government's Guide for the Care and Use of Laboratory Animals were followed in conducting this investigation. The protocol was approved by the Landesamt für Natur, Umwelt und Verbraucherschutz, LANUV AZ 84-02.04.2011.A374 and 84-02.05.20.12.268 Committee on the Ethics of Animal Experiments of the relevant authorities. All animals were kept at the Central Animal Facility under the same guidelines (free access to food and water, 12:12 h light/dark cycles).

Oocytes for IVF were removed from the tubal ampulla 14 hours following hCG-induced ovulation, as previously mentioned. Oocytes from the control group were used for IVF right away, but oocytes from the experimental groups were aged for an additional 2, 4, 6, or 8 hours following retrieval before IVF. The control group's mean two-cell embryo rate at 24 hours after IVF was 81.5% 10.2 and remained stable following fertilisation of oocytes that had been postovulatory aged for up to eight hours.

To support pre- and post-implantation embryo development, oocyte competency is essential. Postovulatory ageing, which begins at ovulation and continues continually, may reduce this capacity. A prolonged stay in the oviduct prior to in vitro or in vivo fertilisation using assisted reproductive technologies (ART) might cause postovulatory oocyte ageing. Even if eggs can continue to be fertilised for several hours.